Felodipine

CLINICAL USE

Calcium-channel blocker:Hypertension Angina

DOSE IN NORMAL RENAL FUNCTION

Hypertension: 5–20 mg once dailyAngina: 5–10 mg daily

PHARMACOKINETICS

Molecular weight :384.3

%Protein binding :99

%Excreted unchanged in urine : <0.5

Volume of distribution (L/kg) :10

half-life – normal/ESRD (hrs) :24/Unchanged

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Not dialysed. Dose as in normal renal function

CAV/VVHD :Not dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Anaesthetics: enhanced hypotensive effect

Antibacterials: metabolism possibly inhibited by erythromycin

Anti-epileptics: effect reduced by carbamazepine, barbiturates, phenytoin and primidone

Antifungals: metabolism inhibited by itraconazole and ketoconazoleAntihypertensives: enhanced hypotensive effect, increased risk of first dose hypotensive effect of post-synaptic alpha-blockers

Antivirals: concentration possibly increased by ritonavir

Grapefruit juice: concentration increased – avoid concomitant use

Tacrolimus: possibly increased tacrolimus concentrationTheophylline: possibly increased theophylline concentration

ADMINISTRATION

Reconstition

–

Route

Oral

Rate of Administration

–

Comments

–

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

Home