H2-blocker:Conditions associated with hyperacidity

20–80 mg dailyZollinger-Ellison syndrome: 80–800 mg daily in divided doses

Molecular weight :337.4

%Protein binding :15–20

%Excreted unchanged in urine : 25–30

Volume of distribution (L/kg) :1.1–1.4

half-life – normal/ESRD (hrs) :3/>20

20 to 50 : Dose as in normal renal function

10 to 20 : 50% of normal dose

<10 : 20 mg at night (maximum)

CAPD :Not dialysed. Dose as in GFR <10 mL/min

HD :Not dialysed. Dose as in GFR <10 mL/min

HDF/high flux :Not dialysed. Dose as in GFR <10 mL/min

CAV/VVHD :Not dialysed. Dose as in GFR=10–20 mL/min

Potentially hazardous interactions with other drugs

Antifungals: absorption of itraconazole and ketoconazole reduced

Ciclosporin: possibly increased ciclosporin levelsCytotoxics: possibly reduced dasatinib concentration

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Oral

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