Palonosetron

Anti-emetic:For use with cancer chemotherapy

250 mcg as a single dose approximately 30 minutes before chemotherapy

Molecular weight :332.9 (as hydrochloride)

%Protein binding :62

%Excreted unchanged in urine : 40

Volume of distribution (L/kg) :6.9–7.9

half-life – normal/ESRD (hrs) :40

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD :Unlikely to be dialysed. Dose as in normal renal function

HD :Unlikely to be dialysed. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unlikely to be dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugsNone

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IV bolus

30 seconds

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Repeated doses within 7 days are not recommendedUse with caution in people at risk of QT prolongation.