norfloxacin
CLINICAL USE
Antibacterial agent
DOSE IN NORMAL RENAL FUNCTION
400 mg twice daily, duration of course depends on indication
PHARMACOKINETICS
Molecular weight :319.3 %Protein binding :14 %Excreted unchanged in urine : 30 Volume of distribution (L/kg) :2.5–3.1half-life – normal/ESRD (hrs) :3–4/6.5–8 DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
30–50 Dose as in normal renal function 10–30 400 mg every 12 to 24 hours <10 : 400 mg daily DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD :Not dialysed. Dose as in GFR <10 mL/min HD :Not dialysed. Dose as in GFR <10 mL/minHDF/high flux :Unknown dialysability. Dose as in GFR <10 mL/minCAV/VVHD :Not dialysed. Dose as in GFR=10–30 mL/min IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsAnalgesics: increased risk of convulsions with NSAIDsAnticoagulants: anticoagulant effect of coumarins enhancedAntimalarials: manufacturer of artemether with lumefantrine advises avoid concomitant useCiclosporin: increased risk of nephrotoxicityTheophylline: possibly increased risk of convulsion; increased levels of theophylline ADMINISTRATION
Reconstition
– Route
Oral Rate of Administration
–Comments
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See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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