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CLINICAL USE

Antifungal agent

DOSE IN NORMAL RENAL FUNCTION

Oral: 100 000–1 000 000 units (1–10 mL) every 6 hoursTopical: Apply 2–4 times daily (depends on formulation)

PHARMACOKINETICS

  • Molecular weight                           :926.1
  • %Protein binding                           :No data
  • %Excreted unchanged in urine     : No data
  • Volume of distribution (L/kg)       :No data
  • half-life – normal/ESRD (hrs)      :No data

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Not dialysed. Dose as in normal renal function
  • HD                     :Not dialysed. Dose as in normal renal function
  • HDF/high flux   :Not dialysed. Dose as in normal renal function
  • CAV/VVHD      :Not dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs
  • None known

    ADMINISTRATION

    Reconstition

    Route

    Oral, topical

    Rate of Administration

    Comments

    OTHER INFORMATION

    Not absorbed from intact skin or mucous membranesNo significant gastrointestinal absorption



    See how to identify renal failure stages according to GFR calculation

    See how to diagnose irreversible renal disease

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