Paclitaxel
CLINICAL USE
Ovarian and breast cancer Non-small cell lung carcinoma AIDS-related Kaposi’s sarcoma
DOSE IN NORMAL RENAL FUNCTION
100–220 mg/m2 every 3 weeks depending on local regime and duration of infusion
PHARMACOKINETICS
Molecular weight                           :853.9 %Protein binding                           :89–98 %Excreted unchanged in urine     : 1.3–12.6 Volume of distribution (L/kg)       :198–688 litres/m2half-life – normal/ESRD (hrs)      :3–52.7 DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Dose as in normal renal function DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unlikely to be dialysed. Dose as in normal renal function HD                     :Not dialysed. Dose as in normal renal functionHDF/high flux   :Unknown dialysability. Dose as in normal renal functionCAV/VVHD      :Unknown dialysability. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsAntidiabetics: metabolism of rosiglitazone possibly inhibitedAntipsychotics: avoid concomitant use with clozapine (increased risk of agranulocytosis) ADMINISTRATION
Reconstition
– Route
IV Rate of Administration
3 hours depending on regime Comments
Dilute to a concentration of 0.3–1.2 mg/ mL with sodium chloride 0.9% or glucose 5%Stable for 27 hours at room temperature OTHER INFORMATION
Administer through a 0.22µm in line filter Use non-PVC infusion bags Hepatic metabolism and biliary clearance are the principal mechanisms for disposal. Mean values for cumulative urinary recovery of unchanged drug ranged from 1.3 to 12.6% of the dose, indicating extensive non-renal clearance.
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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