Tamoxifen

CLINICAL USE

Treatment of breast cancer Anovulatory infertility

DOSE IN NORMAL RENAL FUNCTION

Breast cancer: 20 mg daily Anovulatory infertility: 20–80 mg daily

PHARMACOKINETICS

Molecular weight :371.5; (563.6 as citrate)

%Protein binding :>99

%Excreted unchanged in urine : 0

Volume of distribution (L/kg) :20

half-life – normal/ESRD (hrs) :7 days/Probably unchanged

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Unknown dialysability. Dose as in normal renal function

HD :Unknown dialysability. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Anticoagulants: effects of coumarins enhanced

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

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Comments

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OTHER INFORMATION

Tamoxifen has been used for the treatment of encapsulating peritoneal sclerosis, at a dose of 20 mg daily. Four consecutive cases of peritoneal dialysis-related encapsulating peritoneal sclerosis treated successfully with tamoxifen.

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

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