Cinnarizine
Cinnarizine.JPG

Cinnarizine

CLINICAL USE

Vestibular disorders Motion sickness

DOSE IN NORMAL RENAL FUNCTION

Vestibular disorders: 30 mg 3 times a day Motion sickness: 30 mg 2 hours before travel then 15 mg every 8 hours when required

PHARMACOKINETICS

  • Molecular weight                           :368.5
  • %Protein binding                           :80
  • %Excreted unchanged in urine     : <20
  • Volume of distribution (L/kg)       :No data
  • half-life – normal/ESRD (hrs)      :3–6/–

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Unlikely to be dialysed. Dose as in normal renal function
  • HD                     :Unlikely to be dialysed. Dose as in normal renal function
  • HDF/high flux   :Unknown dialysability. Dose as in normal renal function
  • CAV/VVHD      :Unlikely to be dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugsNone known

    ADMINISTRATION

    Reconstition

    Route

    Oral

    Rate of Administration



    See how to identify renal failure stages according to GFR calculation

    See how to diagnose irreversible renal disease

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