Humanised murine/human monoclonal anti-CD25 antibody:Prophylaxis of acute allograft rejection, in combination with maintenance immunosuppressants

1 mg/kg within 24 hours of transplantation, then 1 mg/kg every 14 days for 5 doses. See ‘Other Information’

Molecular weight :144 000

%Protein binding :No data

%Excreted unchanged in urine : No data

Volume of distribution (L/kg) :5.3 litres

half-life – normal/ESRD (hrs) :270–919/–

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD :Not dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unlikely to be dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugsNone known

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Over 15 minutes

Add required dose to 50 mL of sodium chloride 0.9%Stable for 24 hours at 2–8°C if prepared aseptically

An alternative dosing regimen that may be used is 2 mg/kg every 14 days for 2 doses