Cyclizine.JPG

Cyclizine

CLINICAL USE

Nausea and vomiting Vertigo Motion sickness Labyrinthine disorders

DOSE IN NORMAL RENAL FUNCTION

50 mg up to 3 times daily

PHARMACOKINETICS

  • Molecular weight                           :266.4
  • %Protein binding                           :No data
  • %Excreted unchanged in urine     : <1
  • Volume of distribution (L/kg)       :No data
  • half-life – normal/ESRD (hrs)      :20/–

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Unknown dialysability. Dose as in normal renal function
  • HD                     :Unknown dialysability. Dose as in normal renal function
  • HDF/high flux   :Unknown dialysability. Dose as in normal renal function
  • CAV/VVHD      :Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugsNone known

    ADMINISTRATION

    Reconstition

    Route

    IV, IM, oral

    Rate of Administration

    Slow IV

    Comments

    Increased cerebral sensitivity in patients with renal failure