Cyclizine
Cyclizine
CLINICAL USE
Nausea and vomiting Vertigo Motion sickness Labyrinthine disorders
DOSE IN NORMAL RENAL FUNCTION
50 mg up to 3 times daily
PHARMACOKINETICS
Molecular weight                           :266.4 %Protein binding                           :No data %Excreted unchanged in urine     : <1 Volume of distribution (L/kg)       :No datahalf-life – normal/ESRD (hrs)      :20/– DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Dose as in normal renal function DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unknown dialysability. Dose as in normal renal function HD                     :Unknown dialysability. Dose as in normal renal functionHDF/high flux   :Unknown dialysability. Dose as in normal renal functionCAV/VVHD      :Unknown dialysability. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsNone known ADMINISTRATION
Reconstition
– Route
IV, IM, oral Rate of Administration
Slow IV Comments
Increased cerebral sensitivity in patients with renal failure
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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