Meptazinol

CLINICAL USE

Opioid analgesic used for moderate to severe pain

DOSE IN NORMAL RENAL FUNCTION

Oral: 200 mg every 3–6 hours IM: 75–100 mg every 2–4 hours; obstetric analgesia: 100–150 mg depending on patient’s weight (2 mg/kg)IV: 50–100 mg every 2–4 hours

PHARMACOKINETICS

Molecular weight :269.8 (as hydrochloride)

%Protein binding :27

%Excreted unchanged in urine : <5

Volume of distribution (L/kg) :3.1

half-life – normal/ESRD (hrs) :1.4–4

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function. Start with low doses

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Unknown dialysability. Dose as in GFR <10 mL/min

HD :Likely dialysability. Dose as in GFR <10 mL/min

HDF/high flux :Likely dialysability. Dose as in GFR <10 mL/min

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Antidepressants: possible CNS excitation or depression with MAOIs – avoid concomitant use; possible CNS excitation or depression with moclobemide; possibly increased sedative effects with tricyclicsSodium oxybate: enhanced effect of sodium oxybate – avoid concomitant use

ADMINISTRATION

Reconstition

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Route

Oral, IV, IM

Rate of Administration

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Comments

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OTHER INFORMATION

Oral and IM peak analgesic effect occurs within 30–60 minutes and last for 3–4 hoursIV works immediately and lasts for at least 1 hour.

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

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