Cefalexin
Cefalexin
CLINICAL USE
Antibacterial agent
DOSE IN NORMAL RENAL FUNCTION
250 mg every 6 hours or 500 mg every 8–12 hours; maximum 6 g dailyRecurrent UTI prophylaxis: 125 mg at night
PHARMACOKINETICS
Molecular weight :365.4 %Protein binding :15 %Excreted unchanged in urine : 80–90 Volume of distribution (L/kg) :0.35half-life – normal/ESRD (hrs) :1/16 DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50 : Dose as in normal renal function 10 to 20 : 500 mg every 8–12 hours <10 : 250–500 mg every 8–12 hours DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD :dialysed. Dose as in GFR <10 : mL/min HD :Dialysed. Dose as in GFR <10 : mL/min HDF/high flux :Dialysed. Dose as in GFR <10 : mL/min CAV/VVHD :Dialysed. Dose as in GFR=10–20 mL/min IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsAnticoagulants: effects of coumarins may be enhanced ADMINISTRATION
Reconstition
– Route
Oral Rate of Administration
–Comments
– OTHER INFORMATION
Use dose for normal renal function to treat urinary tract infection in ERFHigh doses, together with the use of nephrotoxic drugs such as aminoglycosides or potent diuretics, may adversely affect renal function
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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