Temazepam
CLINICAL USE
Benzodiazepine:Insomnia (short-term use) Pre-med anxiolytic prior to minor procedures
DOSE IN NORMAL RENAL FUNCTION
10–40 mg at night Premedication: 20–40 mg, 60 minutes prior to procedure
PHARMACOKINETICS
Molecular weight :300.7 %Protein binding :96 %Excreted unchanged in urine : <2 Volume of distribution (L/kg) :1.3–1.5half-life – normal/ESRD (hrs) :7–11/Unchanged DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50 : Dose as in normal renal function 10 to 20 : Dose as in normal renal function. Start with small doses <10 : Dose as in normal renal function. Start with small doses DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD :Unlikely to be dialysed. Dose as in GFR <10 mL/min HD :Not dialysed. Dose as in GFR <10 mL/minHDF/high flux :Unknown dialysability. Dose as in GFR <10 mL/min CAV/VVHD :Not dialysed. Dose as in GFR 10 to 20 mL/min IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsAntibacterials: metabolism possibly increased by rifampicinAntipsychotics: increased sedative effects Antivirals: concentration possibly increased by ritonavirDisulfiram: metabolism of temazepam inhibited (increased toxicity)Sodium oxybate: enhanced effects of sodium oxybate – avoid ADMINISTRATION
Reconstition
– Route
Oral Rate of Administration
–Comments
– OTHER INFORMATION
Increased CNS sensitivity in renal impairmentLong-term use may lead to dependence and withdrawal symptoms in certain patients80% of metabolites excreted in the urine
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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