Temocillin

Antibacterial agent

1–2 g every 12 hoursAcute uncomplicated UTIs: 1 g daily in a single or divided doses

Molecular weight :458.4 (as sodium salt)

%Protein binding :75–85

%Excreted unchanged in urine : 90

Volume of distribution (L/kg) :0.23

half-life – normal/ESRD (hrs) :3.1–5.4/28.2

30–50 Dose as in normal renal function 10–30 1–2 g daily

<10 : 1–2 g every 48 hours

CAPD :Not dialysed. Dose as in GFR <10 mL/min

HD :Dialysed. Dose as in GFR <10 mL/min

HDF/high flux :Dialysed. Dose as in GFR <10 mL/min

CAV/VVHD :Dialysed. Dose as in GFR=10–30 mL/min

Potentially hazardous interactions with other drugsTemocillin can reduce the excretion of methotrexate (increased risk of toxicity)

IV: Dissolve in 20 mL water for injection

: Dilute in 50–100 mL sodium chloride 0.9%IM: Dissolve in 2 mL water for injection or lidocaine 0.5–1% (volume 2.7 mL)

IV, IM

Slow IV bolus over 3–4 minutes Infusion over 30–40 minutes

Incompatible with proteins, blood products, lipid emulsions and aminoglycosides

Bleeding has occurred in some patients (more likely in those with renal impairment)20% is removed by haemodialysis and 17–26% by peritoneal dialysis.