Colestyramine.JPG

Colestyramine

CLINICAL USE

Hyperlipidaemias Pruritus associated with partial biliary obstruction and primary biliary cirrhosisDiarrhoeal disorders

DOSE IN NORMAL RENAL FUNCTION

Lipid reduction: 12–24 g daily (in single or up to 4 divided doses). Maximum 36 g dailyPruritus: 4–8 g daily Diarrhoeal disorders: 12–24 g daily. Maximum 36 g daily

PHARMACOKINETICS

  • Molecular weight                           :–
  • %Protein binding                           :0
  • %Excreted unchanged in urine     : 0
  • Volume of distribution (L/kg)       :Not absorbed
  • half-life – normal/ESRD (hrs)      :Not absorbed

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Not dialysed. Dose as in normal renal function
  • HD                     :Not dialysed. Dose as in normal renal function
  • HDF/high flux   :Not dialysed. Dose as in normal renal function
  • CAV/VVHD      :Not dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugsAnticoagulants: effect of coumarins and phenindione may be enhanced or reducedCiclosporin: may interact unpredictably with ciclosporin. Take ciclosporin at least 1 hour before or 4–6 hours after to prevent problems with absorptionLeflunomide: avoid concomitant use Raloxifene, thyroid hormones, bile acids, valproate, cardiac glycosides and mycophenolate mofetil: absorption reduced

    ADMINISTRATION

    Reconstition

    Mix with water, or a suitable liquid such as fruit juice, and stir to a uniform consistencyMay also be mixed with skimmed milk, thin soups, apple sauce, etc

    Route

    Oral

    Rate of Administration

    Comments

    Do not take in dry form Administer other drugs at least one hour before or 4–6 hours after colestyraminePrepare powder immediately prior to administration

    OTHER INFORMATION

    Hyperchloraemic acidosis occasionally reported on prolonged use of colestyramineOn chronic use, an increased bleeding tendency may occur associated with vitamin K deficiency