Colestyramine

CLINICAL USE

Hyperlipidaemias Pruritus associated with partial biliary obstruction and primary biliary cirrhosisDiarrhoeal disorders

DOSE IN NORMAL RENAL FUNCTION

Lipid reduction: 12–24 g daily (in single or up to 4 divided doses). Maximum 36 g dailyPruritus: 4–8 g daily Diarrhoeal disorders: 12–24 g daily. Maximum 36 g daily

PHARMACOKINETICS

Molecular weight :–

%Protein binding :0

%Excreted unchanged in urine : 0

Volume of distribution (L/kg) :Not absorbed

half-life – normal/ESRD (hrs) :Not absorbed

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Not dialysed. Dose as in normal renal function

CAV/VVHD :Not dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsAnticoagulants: effect of coumarins and phenindione may be enhanced or reducedCiclosporin: may interact unpredictably with ciclosporin. Take ciclosporin at least 1 hour before or 4–6 hours after to prevent problems with absorptionLeflunomide: avoid concomitant use Raloxifene, thyroid hormones, bile acids, valproate, cardiac glycosides and mycophenolate mofetil: absorption reduced

ADMINISTRATION

Reconstition

Mix with water, or a suitable liquid such as fruit juice, and stir to a uniform consistencyMay also be mixed with skimmed milk, thin soups, apple sauce, etc

Route

Oral

Rate of Administration

–

Comments

Do not take in dry form Administer other drugs at least one hour before or 4–6 hours after colestyraminePrepare powder immediately prior to administration

OTHER INFORMATION

Hyperchloraemic acidosis occasionally reported on prolonged use of colestyramineOn chronic use, an increased bleeding tendency may occur associated with vitamin K deficiency

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

Home