Vardenafil
CLINICAL USE
Treatment of erectile dysfunction
DOSE IN NORMAL RENAL FUNCTION
5–20 mg approximately 25–60 minutes before sexual activity
PHARMACOKINETICS
Molecular weight : 488.6 %Protein binding : 95 %Excreted unchanged in urine : 2–6 Volume of distribution (L/kg) : 208 litres half-life – normal/ESRD (hrs) : 4–5 DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
Initial doses as for normal renal function, then maintenance doses of: 30–50 Dose as in normal renal function 10–30 Initial dose 5 mg and adjust accordingly <10 : Initial dose 5 mg and adjust accordingly DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD : Not dialysed. Dose as in GFR <10 mL/min. Use with caution HD : Not dialysed. Dose as in GFR <10 mL/min. Use with caution HDF/high flux : Unknown dialysability. Dose as in GFR <10 mL/min. Use with caution CAV/VVHD : Not dialysed. Dose as in GFR=10–30 mL/min IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugs Alpha-blockers: enhanced hypotensive effect – avoid for 6 hours after alpha- blockers (max dose 5 mg) Antifungals: concentration increased by ketoconazole, and itraconazole – avoid concomitant use Antivirals: concentration increased by amprenavir, indinavir, ritonavir, saquinavir – avoid with indinavir and ritonavir; reduce initial dose with saquinavir Grapefruit juice: concentration possibly increased – avoid concomitant use Nicorandil: possibly enhanced hypotensive effect – avoid concomitant use Nitrates: possibly enhanced hypotensive effect – avoid concomitant use ADMINISTRATION
Reconstition
– Route
Oral Rate of Administration
– Comments
– OTHER INFORMATION
Contraindicated in dialysis patients due to lack of information, therefore suggest use with caution and monitor patients closely .
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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