Varenicline

Aid to smoking cessation

0.5 mg once daily for 3 days, 0.5 mg twice daily for 3 days, then 0.5–1 mg twice daily

Molecular weight : 361.3 (as tartrate)

%Protein binding : <20

%Excreted unchanged in urine : 92

Volume of distribution (L/kg) : 415 litres

half-life – normal/ESRD (hrs) : 24/Increased

Initial doses as for normal renal function, then maintenance doses of: 30–50 1 mg once or twice daily 10–30 1 mg once daily

<10 : 0.5–1 mg once daily

CAPD : Unknown dialysability. Dose as in GFR <10 mL/min

HD : Dialysed. Dose as in GFR <10 mL/min

HDF/high flux : Dialysed. Dose as in GFR <10 mL/min

CAV/VVHD : Dialysed. Dose as in GFR=10–30 mL/min

Potentially hazardous interactions with other drugs

None known

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Oral

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