tazocin

CLINICAL USE

Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION

2.25–4.5 g every 6–8 hours

PHARMACOKINETICS

Molecular weight :Piperacillin: 539.5, Tazobactam: 322.3 (as sodium)

%Protein binding :Piperacillin: 20–30, Tazobactam: 20–30

%Excreted unchanged in urine : Piperacillin: 60–80, Tazobactam: 80

Volume of distribution (L/kg) :Piperacillin: 0.18–0.3, Tazobactam: 0.18–0.331

half-life – normal/ESRD (hrs) :Piperacillin: 1/4–6, Tazobactam: 1/7

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : 4.5 g every 8–12 hours, or 2.25 g every 6 hours

<10 : 4.5 g every 12 hours, or 2.25 g every 8 hours

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in GFR

<10 : mL/minute

HD :Dialysed. Dose as in GFR

<10 : mL/minute

HDF/high flux :Dialysed. Dose as in GFR

<10 : mL/minute

CAV/VVHD :Dialysed. Dose as in GFR=10–20 mL/minute, or 2.25 g every 6 hours,1 or 4.5 g every 12 hoursCVVhd/HDFDialysed: 2.25–3.375 g every 6 hours,1 or 4.5 g every 8 hours

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsReduced excretion of methotrexate – monitor methotrexate levels during concomitant treatmentEnhanced action of vecuronium and similar neuromuscular blocking agents

ADMINISTRATION

Reconstition

Reconstitute each 4.5 g with 20 mL sterile water for injection or sodium chloride 0.9%

Route

Rate of Administration

IV bolus over 3–5 minutes

IV infusion

over 20–30 minutes

Comments

May be given as an infusion in glucose 5% or sodium chloride 0.9%

OTHER INFORMATION

Sodium content is 2.79 mmol/g of injectionHas been used intraperitoneally for treatment of PD peritonitis at a concentration of 250 mg/LPatients with renal impairment are at a greater risk of neuromuscular excitability or convulsions that are associated with overdoseMay cause in vitro inactivation of aminoglycosides6–21% is removed by peritoneal dialysis and 30–50% by haemodialysis plus an extra 5% as the metabolite

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

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