Tenecteplase

Thrombolytic:Acute myocardial infarction

30–50 mg depending on patient weight (500–600 micrograms/kg)

Molecular weight :70 000

%Protein binding :No data

%Excreted unchanged in urine : Minimal

Volume of distribution (L/kg) :6.1–9.1 litres1 (weight and dose related)

half-life – normal/ESRD (hrs) :90–130 minutes/Unchanged

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD :Unlikely to be dialysed. Dose as in normal renal function

HD :Unlikely to be dialysed. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

Potentially hazardous interactions with other drugsDrugs that affect coagulation or platelet function: increased risk of bleeding

Water for injection

Over 10 seconds

Incompatible with dextrose

It has an initial half-life of 20–24 minutes Cleared mainly by hepatic metabolism Re-administration is not recommended due to lack of experience