Antibacterial agent

500 mg – 1 g every 12–24 hours

Molecular weight :381.4

%Protein binding :20

%Excreted unchanged in urine : >90

Volume of distribution (L/kg) :0.31

half-life – normal/ESRD (hrs) :1.3–2/22

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : 500 mg – 1 g every 24 hours

CAPD :Not dialysed. Dose as in GFR <10 mL/min

HD :Dialysed. Dose as in GFR

<10 : mL/min

HDF/high flux :Dialysed. Dose as in GFR

<10 : mL/min

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

Potentially hazardous interactions with other drugsAnticoagulants: effects of coumarins may be enhanced

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Oral

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