Laxative

Oral: 5–10 mg at nightRectal: 10 mg in the morningBowel evacuation:

10 to 20 : mg orally at night followed by 10 mg as suppositories the next morning

Molecular weight :361.4

%Protein binding :Negligible

%Excreted unchanged in urine : 30

Volume of distribution (L/kg) :

half-life – normal/ESRD (hrs) :

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD :Unknown dialysability. Dose as in normal renal function

HD :Unknown dialysability. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

Potentially hazardous interactions with other drugsNone known

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Oral, rectal

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Absorption is <5% orally or rectally

Rapidly converted in the gut (by intestinal and bacterial enzymes) to its active, but non-absorbed, desacetyl metabolite