Antihistamine:Symptomatic relief of allergy such as hay fever, urticaria

10 mg daily

Molecular weight :382.9

%Protein binding :97–99

%Excreted unchanged in urine : 40

Volume of distribution (L/kg) :No data

half-life – normal/ESRD (hrs) :12–15/Unchanged

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD :Not dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unlikely to be dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugs

Antibacterials: concentration possibly increased by erythromycin

Antifungals: concentration of loratadine possibly increased by ketoconazole – avoid concomitant use

Antivirals: concentration possibly increased by amprenavir – avoid concomitant use; concentration possibly increased by ritonavir

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Oral

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Patients with renal impairment are at increased risk of sedation.