Lymecycline

CLINICAL USE

Antibacterial agent:Also used for treatment of acne

DOSE IN NORMAL RENAL FUNCTION

408 mg (1 capsule) twice daily, increasing to 3–4 capsules daily in severe infectionsAcne: 408 mg daily for at least 8 weeks

PHARMACOKINETICS

Molecular weight :602.6

%Protein binding :Approx 25–60

%Excreted unchanged in urine : 25

Volume of distribution (L/kg) :Approx 1.3–1.7

half-life – normal/ESRD (hrs) :10/Increased

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Avoid. See ‘Other Information’

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in GFR <10 mL/min

HD :Not dialysed. Dose as in GFR <10 mL/min

HDF/high flux :Unknown dialysability. Dose as in GFR <10 mL/min

CAV/VVHD :Unlikely to be dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Anticoagulants: possibly enhanced anticoagulant effect of coumarins and phenindione

Oestrogens: possibly reduce contraceptive effects of oestrogens (risk probably small)

Retinoids: possible increased risk of benign intracranial hypertension – avoid concomitant use

ADMINISTRATION

Reconstition

–

Route

Oral

Rate of Administration

–

Comments

Do not take iron preparations, indigestion remedies or phosphate binders at the same time of day as lymecycline

OTHER INFORMATION

Lymecycline is a tetracycline derivative 408 mg lymecycline ≡ 300 mg tetracyclineNot recommended in severe renal impairment as lymecycline is mainly excreted by the kidneys.

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

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