Treatment of PCP if intolerant to co-trimoxazole

750 mg twice daily for 21 days

Molecular weight :366.8

%Protein binding :99.9

%Excreted unchanged in urine : <1

Volume of distribution (L/kg) :0.62 ± 0.19

half-life – normal/ESRD (hrs) :2–3 days/no data

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function. Use with caution

CAPD :Not dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unlikely to be dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugs

Antibacterials: rifampicin, rifabutin and tetracyclines reduce levels by 50%

Metoclopramide: significant reduction in plasma atovaquone levels

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Oral

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Administer with food. The presence of food, particularly high fat food, increases bioavailability 2 or 3-fold.

The most commonly reported abnormalities in laboratory parameters are increased liver function tests and amylase levels, and hyponatraemia