Mizolastine

CLINICAL USE

Antihistamine:Symptomatic relief of allergy, e.g. hayfever, urticaria

DOSE IN NORMAL RENAL FUNCTION

10 mg daily

PHARMACOKINETICS

Molecular weight :432.5

%Protein binding :98.4

%Excreted unchanged in urine : <0.5

Volume of distribution (L/kg) :1.4

half-life – normal/ESRD (hrs) :13

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Not dialysed. Dose as in normal renal function

CAV/VVHD :Not dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Anti-arrhythmics: increased risk of ventricular arrhythmias – avoid concomitant use with amiodarone, disopyramide, flecainide, mexiletine, procainamide and propafenone

Antibacterials: metabolism possibly inhibited by macrolides – avoid concomitant use; increased risk of ventricular arrhythmias with moxifloxacin – avoid concomitant use

Antifungals: metabolism inhibited by itraconazole and ketoconazole and possibly imidazoles – avoid concomitant use

Beta-blockers: increased risk of ventricular arrhythmias with sotalol – avoid concomitant use

Ciclosporin: use with caution due to inhibition of ciclosporin metabolismAvoid concomitant treatment with any drug that could prolong QT intervalCaution with drugs that inhibit cytochrome P450 enzymes (may elevate mizolastine levels)

ADMINISTRATION

Reconstition

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Route

Oral

Rate of Administration

–

Comments

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OTHER INFORMATION

Contraindicated in patients with electrolyte imbalances, particularly hypokalaemia.

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

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