Minocycline

Antibacterial agent

100 mg twice dailyAcne: 100 mg daily in 1 or 2 divided doses

Molecular weight :457.5

%Protein binding :75

%Excreted unchanged in urine : 5–10

Volume of distribution (L/kg) :1–1.5

half-life – normal/ESRD (hrs) :11–26/12–18

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD :Not dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unlikely to be dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugs

Anticoagulants: possibly enhanced anticoagulant effect of coumarins and phenindione

Oestrogens: possibly reduced contraceptive effect of oestrogens (risk probably small)

Retinoids: possibly increased risk of benign intracranial hypertension – avoid concomitant use

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Oral

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Do not take iron preparations, indigestion remedies or phosphate binders at the same time of day as minocycline.