NORADRENALINE

Brand Name & Strength

Cardiamed 4 mg/4 ml, Levophed 4 mg/4 ml, Biemefrin 4mg/4ml

Reconstitution

Not required

Further Dilution

IV infusion

Single strength: Dilute 1 ampoule in 50 ml diluent (0.08 mg/ml) Double strength: Dilute 2 ampoule in 50 ml diluent (0.16 mg/ml) Max concentration: 32 mg/50 ml

Diluent

D5, D5NS

Administration & Infusion rate

Continuous

IV infusion

Dose: 8 – 12 mcg/min; maintenance dose 2 – 4 mcg/min Rate of infusion: As per calculation above Must always be administered through a dedicated lumen of a central line

Storage & Stability

RT

(<25 oC)

Fridge

(2-8 oC)

After Reconstitution

-

After dilution

24 hr

Remarks

D5 is recommended to be used as the diluent as it provides protection against excessive oxidation where subsequently can cause loss of potency Administration with NS is not recommended by the manufacturer but stability in NS has been demonstrated.