BORTEZOMIB

Brand Name & Strength

Bortezomib 1 mg/5 ml, Bortezomib 3.5 mg/10 ml

Reconstitution

IV bolus

(maximum concentration 1 mg/ml) [1,2,3]

Bortezomib 1 mg/5 ml: reconstitute with 1 ml NS

Bortezomib 3.5 mg/10 ml: reconstitute with 3.5 ml NS SC (maximum concentration 2.5 mg/ml) [1,2,3]

Reconstitute each 3.5 mg vial with 1.4 ml NS

Further Dilution

Not required

Diluent

Not required

Administration & Infusion rate

IV bolus

Administer over 3 to 5 seconds SC

Administer into the thigh or abdomen (right or left). Injection sites should be rotated for each successive injections

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

8 hr -

After dilution

3 days (at 1 mg/ml) 5 days (at 1 mg/ml)

Remarks

Do not administer via other route. Death have been reported with intrathecal administration

Bortezomib is an antineoplastic. Caution should be used during handling and preparation

The reconstituted concentrations for IV and SC administrations are different; use caution when calculating the volume for each dose.[1,2]

If local injection site reactions occur following Bortezomib injection subcutaneously, a less concentrated solution (1 mg/ml instead of 2.5 mg/ml) may be administered subcutaneously, or change to IV injection.