AMPHOTERICIN B LIPID COMPLEX

AMPHOTERICIN B LIPID COMPLEX

Brand Name & Strength

Ampholip 50 mg/10 ml

Reconstitution

Not required

Further Dilution

Dilute 1 vial (50 mg) with 40 ml of diluent (concentration: 1 mg/ml). In fluid restricted, pediatric and cardiovascular patient, 2 mg/ml may be used.

Diluent

D5

Administration & Infusion rate

IV infusion

  • Administer at a rate of 2.5 mg/kg/hr

    Storage & Stability

    RT

    (<25 oC)

    Fridge

    (2 – 8 oC)

    After Reconstitution

    - -

    After dilution

    6 hr 48 hr

    Remarks

  • Test dose: 1 mg infused intravenously over 15 min
  • For patients who experience infusion-related immediate reactions, premedicate with an NSAID ± Diphenhydramine or Hydrocortisone.
  • If the infusion time exceeds 2 hours, mix the contents by shaking the infusion bag every 2 hours.
  • Do not dilute with NS or mix with other drugs or electrolytes.
  • Do not use an in-line filter during administration.
  • IV line should be flushed with D5