AMPHOTERICIN B LIPID COMPLEX

Brand Name & Strength

Ampholip 50 mg/10 ml

Reconstitution

Not required

Further Dilution

Dilute 1 vial (50 mg) with 40 ml of diluent (concentration: 1 mg/ml). In fluid restricted, pediatric and cardiovascular patient, 2 mg/ml may be used.

Diluent

D5

Administration & Infusion rate

IV infusion

Administer at a rate of 2.5 mg/kg/hr

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- -

After dilution

6 hr 48 hr

Remarks

Test dose: 1 mg infused intravenously over 15 min

For patients who experience infusion-related immediate reactions, premedicate with an NSAID ± Diphenhydramine or Hydrocortisone.

If the infusion time exceeds 2 hours, mix the contents by shaking the infusion bag every 2 hours.

Do not dilute with NS or mix with other drugs or electrolytes.

Do not use an in-line filter during administration.

IV line should be flushed with D5