sodium chloride

CLINICAL USE

Treatment and prophylaxis of sodium chloride deficiency

DOSE IN NORMAL RENAL FUNCTION

Oral prophylaxis: 40–80 mmol sodium daily, up to a maximum of 200 mmol sodium dailyIV: in severe deficiency 2–3 litres over 2–3 hours then reduce

PHARMACOKINETICS

Molecular weight :58.4

%Protein binding :0

%Excreted unchanged in urine : No data

Volume of distribution (L/kg) :Dependent on the physiological state of the patient at the time

half-life – normal/ESRD (hrs) :No data

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Dialysed. Dose as in normal renal function

HD :Dialysed. Dose as in normal renal function

HDF/high flux :Dialysed. Dose as in normal renal function

CAV/VVHD :Dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugsMay impair the efficacy of antihypertensive drugs in chronic renal failure

ADMINISTRATION

Reconstition

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Route

Oral, IV

Rate of Administration

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Comments

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OTHER INFORMATION

Other regimens: for acute muscular cramps post haemodialysis, 10 mL sodium chloride 30% injection diluted in 100 mL sodium chloride 0.9%, and infused over 30 minutes or in dialysis washbackSodium salts should be administered with caution to patients with congestive heart failure, peripheral or pulmonary oedema, or impaired renal functionSlow sodium ® 600 mg tablet approximately 10 mmol sodium and 10 mmol chloride.

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

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