Antibacterial agent

250 mg every 8 hours (dose may be doubled for more severe infections – maximum 4 g daily)

Molecular weight :385.8

%Protein binding :25

%Excreted unchanged in urine : 60–85

Volume of distribution (L/kg) :0.24–0.35

half-life – normal/ESRD (hrs) :0.5–0.9/2.3–2.8

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : 250 mg every 8 hours

CAPD :Dialysed. 250 mg every 8–12 hours

HD :Dialysed. 250–500 mg every 8 hours

HDF/high flux :Dialysed. 250–500 mg every 8 hours

CAV/VVHD :Dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugs

Anticoagulants: effects of coumarins may be enhanced

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Oral

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Cefaclor associated with protracted skin reactions.