oxazepam

Benzodiazepine:Anxiolytic Insomnia

Anxiolytic: 15–30 mg 3 or 4 times a dayInsomnia: 15–50 mg at night

Molecular weight :286.7

%Protein binding :85–97

%Excreted unchanged in urine : <1

Volume of distribution (L/kg) :0.6–1.6

half-life – normal/ESRD (hrs) :3–21/25–90

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Start at low dose and increase according to response

CAPD :Not dialysed. Dose as in GFR <10 mL/min

HD :Not dialysed. Dose as in GFR <10 mL/min

HDF/high flux :Unknown dialysability. Dose as in GFR <10 mL/min

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

Potentially hazardous interactions with other drugs

Antibacterials: metabolism possibly increased by rifampicin

Antipsychotics: enhanced sedative effects

Antivirals: possibly increased concentration with ritonavir
Sodium oxybate: enhanced effects of sodium oxybate – avoid

Ulcer-healing drugs: metabolism inhibited by cimetidine

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Oral

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Protein binding decreased and volume of distribution increased in glucuronide metabolite accumulates in CKD 5; significance of this unknown.