ofloxacin
CLINICAL USE
Antibacterial agent
DOSE IN NORMAL RENAL FUNCTION
Oral: 200–400 mg daily, increased if necessary to 400 mg twice dailyIV: 200–400 mg twice daily
PHARMACOKINETICS
Molecular weight :361.4 %Protein binding :25 %Excreted unchanged in urine : 65–80 Volume of distribution (L/kg) :1.5–2.5half-life – normal/ESRD (hrs) :4–6/15–60 DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50 : 200–400 mg once daily 10 to 20 : 200–400 mg once daily <10 : 200 mg once daily DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD :Not significantly dialysed. Dose as in GFR <10 mL/min HD :Dialysed. Dose as in GFR <10 : mL/min HDF/high flux :Dialysed. Dose as in GFR <10 : mL/min CAV/VVHD :Dialysed. Dose as in GFR=10–20 mL/min IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsAnalgesics: increased risk of convulsions with NSAIDsAnticoagulants: effect of acenocoumarol and warfarin enhancedAntimalarials: manufacturer of artemether with lumefantrine advises avoid concomitant useCiclosporin: increased risk of nephrotoxicityTheophylline: possibly increased risk of convulsions ADMINISTRATION
Reconstition
– Route
Oral, IV Rate of Administration
200 mg over 30 minutes Comments
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See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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