Desirudin
Desirudin
CLINICAL USE
Prophylaxis of DVT in patients undergoing orthopaedic surgery
DOSE IN NORMAL RENAL FUNCTION
15 mg 5–15 minutes before surgery then 15 mg twice daily for 9–12 days or until mobile
PHARMACOKINETICS
Molecular weight                           :6963.4 %Protein binding                           :No data %Excreted unchanged in urine     : 40–50 Volume of distribution (L/kg)       :0.25half-life – normal/ESRD (hrs)      :2–3 DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
31–60 Initially 5 mg twice daily. Aim for APTT <0.85 seconds<31 Initially 1.7 mg twice daily and monitor APTT DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Not dialysed. Dose as in GFR<31 mL/min HD                     :Not dialysed. Dose as in GFR<31 mL/minHDF/high flux   :Unknown dialysability. Dose as in GFR<31 mL/minCAV/VVHD      :Not dialysed. Dose as in GFR<31 mL/min IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsAnticoagulants, antiplatelets, fondaparinux, NSAIDs, heparin and dextran – increased risk of bleeding ADMINISTRATION
Reconstition
With diluent supplied Route
SC Rate of Administration
–Comments
– OTHER INFORMATION
The effect is poorly reversible APTT levels can be reduced by IV DDAVP Available on a named patient basis from Aventis Pharma7% of dose is metabolised by the kidneys
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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