Antihistamine:Symptomatic relief of allergy such as hay fever, urticaria

5 mg daily

Molecular weight :310.8

%Protein binding :83–87

%Excreted unchanged in urine : 40.6 (as active metabolites)

Volume of distribution (L/kg) :No data

half-life – normal/ESRD (hrs) :27/Increased

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD :Not dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Unlikely to be dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugsNone known

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Oral

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Desloratadine is an active metabolite of loratadineFull dose may result in increased sedation in patients with GFR <10 mL/min