HEALTHY LIFESTYLE




Almotriptan
Almotriptan.JPG

Almotriptan

CLINICAL USE

Acute relief of migraine

DOSE IN NORMAL RENAL FUNCTION

12.5 mg repeated after 2 hours if migraine recurs (do not take 2nd dose for the same attack) Maximum 25 mg in 24 hours

PHARMACOKINETICS

  • Molecular weight                           : 469.6 (as malate)
  • %Protein binding                           : 35
  • %Excreted unchanged in urine     : 40–50
  • Volume of distribution (L/kg)       : 195 litres
  • half-life – normal/ESRD (hrs)      : 3.5/7

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

    30–50 Dose as in normal renal function 10–30 6.25 mg; maximum daily dose 12.5 mg. Use with caution
  • <10           : 6.25 mg; maximum daily dose 12.5 mg. Use with caution

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                : Unknown dialysability. Dose as in GFR <10 mL/min
  • HD                     : Likely dialysability. Dose as in GFR <10 mL/min
  • HDF/high flux   : Likely dialysability. Dose as in GFR <10 mL/min
  • CAV/VVHD      : Unknown dialysability. Dose as in GFR=10–30 mL/min

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs
  • Antidepressants: possibly increased serotonergic effects with duloxetine; increased serotonergic effects with St John’s wort – avoid concomitant use
  • Antifungals: concentration increased by ketoconazole (increased risk of toxicity)
  • Ergot alkaloids: increased risk of vasospasm

    ADMINISTRATION

    Reconstition

    Route

    Oral

    Rate of Administration

    Comments

  • other drugs