Tigecycline

Antibacterial agent

Loading dose of 100 mg, then 50 mg twice daily

Molecular weight : 585.6

%Protein binding : 71–89

%Excreted unchanged in urine : 22

Volume of distribution (L/kg) : 7–9

half-life – normal/ESRD (hrs) : 42/Probably unchanged

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD : Not dialysed. Dose as in normal renal function

HD : Not dialysed. Dose as in normal renal function

HDF/high flux : Unknown dialysability. Dose as in normal renal function

CAV/VVHD : Unknown dialysability. Dose as in normal renal function

Potentially hazardous interactions with other drugs

Anticoagulants: possibly enhanced anticoagulant effect of coumarins

Oestrogens: possibly reduced contraceptive effects of oestrogens (risk probably small)

5.3 mL of sodium chloride 0.9% or glucose 5% (gently swirl to reconstitute)

30–60 minutes

Add required dose to 100 mL of sodium chloride 0.9% or glucose 5%

AUC increased by 30% in CKD 5 .