Phenindione
CLINICAL USE
Anticoagulant
DOSE IN NORMAL RENAL FUNCTION
Day 1: 200 mgDay 2: 100 mgMaintenance dose: 50–150 mg daily according to INR
PHARMACOKINETICS
Molecular weight                           :222.2 %Protein binding                           :>97 %Excreted unchanged in urine     : No data Volume of distribution (L/kg)       :No datahalf-life – normal/ESRD (hrs)      :5–6/– DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Dose as in normal renal function DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unknown dialysability. Dose as in normal renal function HD                     :Unknown dialysability. Dose as in normal renal functionHDF/high flux   :Unknown dialysability. Dose as in normal renal functionCAV/VVHD      :Unknown dialysability. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsThere Are Many Significant Interactions With Coumarins. Prescribe With Care With Regard To The Following:Anticoagulant effect enhanced by: alcohol, amiodarone, anabolic steroids, aspirin, azithromycin, aztreonam, bicalutamide, cephalosporins, chloramphenicol, cimetidine, ciprofloxacin, clarithromycin, clopidogrel, cranberry juice, danazol, dextropropoxyphene, dipyridamole, disulfiram, erythromycin, esomeprazole, ezetimibe, fibrates, fluconazole, flutamide, fluvastatin, grapefruit juice, itraconazole, ketoconazole, levamisole, levofloxacin, macrolides, methylphenidate, metronidazole, miconazole, nalidixic acid, neomycin, norfloxacin, NSAIDs, ofloxacin, omeprazole, pantoprazole, paracetamol, penicillins, propafenone, ritonavir, rosuvastatin, SSRIs, simvastatin, sitaxentan, sulfinpyrazone, sulphonamides, tamoxifen, testosterone, tetracyclines, thyroxine, tigecycline, toremifene, tramadol, trimethoprim, valproate, voriconazoleAnticoagulant effect decreased by: acitretin, azathioprine, barbiturates, carbamazepine, griseofulvin, mercatopurine, mitotane, oral contraceptives, phenytoin, primidone, rifampicin, St John’s wort – avoid concomitant use, sucralfate, vitamin KAnticoagulant effects enhanced/reduced by: amprenavir, anion exchange resins, corticosteroids, dietary changes, tricyclicsAnalgesics: increased risk of bleeding with IV diclofenac and ketorolac – avoid concomitant useAntidiabetic agents: enhanced hypoglycaemic effect with sulphonylureasCiclosporin: there have been a few reports of altered anticoagulant effect; decreased ciclosporin levels have been seen rarelyCytotoxics: increased risk of bleeding with erlotinib and imatinib; enhanced effect with etoposide, fluorouracil, ifosfamide and sorafenib ADMINISTRATION
Reconstition
– Route
Oral Rate of Administration
–Comments
– OTHER INFORMATION
Titrate dose to INR Enhanced anticoagulant effect in renal impairment, due to reduced protein bindingMetabolites of phenindione often colour the urine pink or orange.
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