Phenindione
Phenindione.JPG

CLINICAL USE

Anticoagulant

DOSE IN NORMAL RENAL FUNCTION

Day 1: 200 mgDay 2: 100 mgMaintenance dose: 50–150 mg daily according to INR

PHARMACOKINETICS

  • Molecular weight                           :222.2
  • %Protein binding                           :>97
  • %Excreted unchanged in urine     : No data
  • Volume of distribution (L/kg)       :No data
  • half-life – normal/ESRD (hrs)      :5–6/–

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Unknown dialysability. Dose as in normal renal function
  • HD                     :Unknown dialysability. Dose as in normal renal function
  • HDF/high flux   :Unknown dialysability. Dose as in normal renal function
  • CAV/VVHD      :Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugsThere Are Many Significant Interactions With Coumarins. Prescribe With Care With Regard To The Following:Anticoagulant effect enhanced by: alcohol, amiodarone, anabolic steroids, aspirin, azithromycin, aztreonam, bicalutamide, cephalosporins, chloramphenicol, cimetidine, ciprofloxacin, clarithromycin, clopidogrel, cranberry juice, danazol, dextropropoxyphene, dipyridamole, disulfiram, erythromycin, esomeprazole, ezetimibe, fibrates, fluconazole, flutamide, fluvastatin, grapefruit juice, itraconazole, ketoconazole, levamisole, levofloxacin, macrolides, methylphenidate, metronidazole, miconazole, nalidixic acid, neomycin, norfloxacin, NSAIDs, ofloxacin, omeprazole, pantoprazole, paracetamol, penicillins, propafenone, ritonavir, rosuvastatin, SSRIs, simvastatin, sitaxentan, sulfinpyrazone, sulphonamides, tamoxifen, testosterone, tetracyclines, thyroxine, tigecycline, toremifene, tramadol, trimethoprim, valproate, voriconazoleAnticoagulant effect decreased by: acitretin, azathioprine, barbiturates, carbamazepine, griseofulvin, mercatopurine, mitotane, oral contraceptives, phenytoin, primidone, rifampicin, St John’s wort – avoid concomitant use, sucralfate, vitamin KAnticoagulant effects enhanced/reduced by: amprenavir, anion exchange resins, corticosteroids, dietary changes, tricyclics
  • Analgesics: increased risk of bleeding with IV diclofenac and ketorolac – avoid concomitant useAntidiabetic agents: enhanced hypoglycaemic effect with sulphonylureas
  • Ciclosporin: there have been a few reports of altered anticoagulant effect; decreased ciclosporin levels have been seen rarelyCytotoxics: increased risk of bleeding with erlotinib and imatinib; enhanced effect with etoposide, fluorouracil, ifosfamide and sorafenib

    ADMINISTRATION

    Reconstition

    Route

    Oral

    Rate of Administration

    Comments

    OTHER INFORMATION

    Titrate dose to INR Enhanced anticoagulant effect in renal impairment, due to reduced protein bindingMetabolites of phenindione often colour the urine pink or orange.



    See how to identify renal failure stages according to GFR calculation

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