Tiotropium

Maintenance treatment of chronic obstructive pulmonary disease

18 micrograms once daily

Molecular weight : 472.4 (as bromide)

%Protein binding : 72

%Excreted unchanged in urine : 14 (of inhaled dose)

Volume of distribution (L/kg) : 32

half-life – normal/ESRD (hrs) : 5–6 days/Increased

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function. Use with caution

<10 : Dose as in normal renal function. Use with caution

CAPD : Unknown dialysability. Dose as in normal renal function. Use with caution

HD : Unknown dialysability. Dose as in normal renal function. Use with caution

HDF/high flux : Unknown dialysability. Dose as in normal renal function. Use with caution

CAV/VVHD : Unknown dialysability. Dose as in normal renal function. Use with caution

Potentially hazardous interactions with other drugs Avoid administration with other anti- cholinergic drugs

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Inhalation

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Not to be used for acute episodes of bronchospasm .