doxycycline

CLINICAL USE

Antibacterial agentProphylaxis/treatment of malaria

DOSE IN NORMAL RENAL FUNCTION

200 mg on day 1, then 100 mg daily; severe infections 200 mg dailyLate latent syphilis: 200 mg twice daily Malaria: treatment: 200 mg once daily; prophylaxis: 100 mg daily

PHARMACOKINETICS

Molecular weight :462.4

%Protein binding :>90

%Excreted unchanged in urine : 33–45

Volume of distribution (L/kg) :0.7

half-life – normal/ESRD (hrs) :18/Unchanged

DOSE IN RENAL IMPAIRMENT

GFR (mL/MIN)

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

CAPD :Not dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Unknown dialysability. Dose as in normal renal function

CAV/VVHD :Not dialysed. Dose as in normal renal function

IMPORTANT DRUG INTERACTIONS

Potentially hazardous interactions with other drugs

Anticoagulants: possibly enhanced anticoagulant effect of coumarins and phenindione

Ciclosporin: possibly increases plasma- ciclosporin concentration

Oestrogens: possibly reduced contraceptive effects of oestrogens (risk probably small)

Retinoids: possible increased risk of benign intracranial hypertension – avoid concomitant use

ADMINISTRATION

Reconstition

–

Route

Oral

Rate of Administration

–

Comments

Do not take iron preparations, indigestion remedies or phosphate binders at the same time of day as doxycycline.

See how to identify renal failure stages according to GFR calculation

See how to diagnose irreversible renal disease

Home