dosage adjustment of Darifenacin in renal failure




Darifenacin.JPG

Darifenacin

CLINICAL USE

Symptomatic treatment of urinary incontinence, frequency or urgency

DOSE IN NORMAL RENAL FUNCTION

7.5–15 mg once daily

PHARMACOKINETICS

  • Molecular weight                           :426.6 (507.5 as hydrobromide)
  • %Protein binding                           :98
  • %Excreted unchanged in urine     : 3
  • Volume of distribution (L/kg)       :163 litres
  • half-life – normal/ESRD (hrs)      :13–19/Unchanged

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function
  • 10 to 20     : Dose as in normal renal function
  • <10           : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Unlikely to be dialysed. Dose as in normal renal function
  • HD                     :Unlikely to be dialysed. Dose as in normal renal function
  • HDF/high flux   :Unlikely to be dialysed. Dose as in normal renal function
  • CAV/VVHD      :Unlikely to be dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugsAntifungals: concentration increased by ketoconazole – avoid concomitant useAntivirals: avoid concomitant use with amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir and tipranavirCalcium-channel blockers: avoid concomitant use with verapamilCiclosporin: avoid concomitant use