Darifenacin
Darifenacin
CLINICAL USE
Symptomatic treatment of urinary incontinence, frequency or urgency
DOSE IN NORMAL RENAL FUNCTION
7.5–15 mg once daily
PHARMACOKINETICS
Molecular weight                           :426.6 (507.5 as hydrobromide) %Protein binding                           :98 %Excreted unchanged in urine     : 3 Volume of distribution (L/kg)       :163 litreshalf-life – normal/ESRD (hrs)      :13–19/Unchanged DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Dose as in normal renal function DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unlikely to be dialysed. Dose as in normal renal function HD                     :Unlikely to be dialysed. Dose as in normal renal functionHDF/high flux   :Unlikely to be dialysed. Dose as in normal renal functionCAV/VVHD      :Unlikely to be dialysed. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsAntifungals: concentration increased by ketoconazole – avoid concomitant useAntivirals: avoid concomitant use with amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir and tipranavirCalcium-channel blockers: avoid concomitant use with verapamilCiclosporin: avoid concomitant use
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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