Loperamide
Loperamide
CLINICAL USE
Antidiarrhoeal agent
DOSE IN NORMAL RENAL FUNCTION
4 mg stat, then 2 mg after each loose stool; maximum 16 mg daily
PHARMACOKINETICS
Molecular weight                           :513.5 %Protein binding                           :80 %Excreted unchanged in urine     : <10           : Volume of distribution (L/kg)       :No datahalf-life – normal/ESRD (hrs)      :9–14/– DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Dose as in normal renal function. Maximum dose usually 12 mg daily depending on tolerability DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unlikely to be dialysed. Dose as in GFR <10 mL/min HD                     :Unlikely to be dialysed. Dose as in GFR <10 mL/minHDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/minCAV/VVHD      :Unlikely to be dialysed. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsNone known ADMINISTRATION
Reconstition
– Route
Oral Rate of Administration
–Comments
– OTHER INFORMATION
In normal doses loperamide may cause excessive drowsiness in CKD 5
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
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