Normal barriers to protein filtration begin in the glomerulus, which consists of unique capillaries that are permeable to fluid and small solutes but effective barriers to plasma proteins.
The adjacent basement membrane and visceral epithelial cells are covered with negatively charged heparan sulfate proteoglycans.
Proteins cross to the tubular fluid in inverse proportion to their size and negative charge.
Proteins with a molecular weight of less than 20,000 pass easily across the glomerular capillary wall.
Conversely, albumin, with a molecular weight of 65,000 Daltons and a negative charge, is restricted under normal conditions.
The smaller proteins are largely reabsorbed at the proximal tubule, and only small amounts are excreted
Adequate protein intake is essential for body energy and avoid depletion
A 1gm of protein for each body kg is good, a rough figure 1gm protein equal 4 gm of meat
High protein diet may affect the kidney
Low protein diet may lead to malnutrition and worsen kidney