SODIUM BICARBONATE

Brand Name & Strength

Pharmaniaga Sodium Bicarbonate 8.4% Injection (10 mEq/10 ml = 10 mmol/10 ml)

Reconstitution

Not required

Further Dilution

IV infusion

Dilute 1 ampoule (10 ml) to 46 ml of diluent to an isotonic concentration of 1.5% w/v SC Dilute 1 ml of Sodium Bicarbonate 8.4% with 4.6 ml WFI (isotonic solution 1.5%)

Diluent

NS, D5, WFI

Administration & Infusion rate

IV infusion

2 – 5 mEq/kg over 4 – 8 hours. Dosage is highly individualized based on patient’s condition, blood pH and carbon dioxide content. Slow IV (for emergency cases) Administer slowly over 5 min (maximum rate in infants: 10 mEq/min) SC To be used only when IV route is not applicable

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- -

After dilution

- -

Remarks

Undiluted hypertonic 8.4% sodium bicarbonate may be given by IV injection during cardiac arrest Avoid rapid infusion, which may cause tetany in children In children, do not administer more than 8 mEq/kg/day Do not give concurrently with calcium or catecholamine. If patient is receiving any of these drugs, flush IV line thoroughly after each dose