GLYCERYL TRINITRATE

Brand Name & Strength

Gitrinil Injection 50 mg/10 ml

Reconstitution

Not required

Further Dilution

IV infusion

Dilute 50 mg in 500 ml diluent (100 mcg/ml)

Dilute 50 mg in 250 ml diluent. Alternatively use 10 mg in 50 ml diluent (200 mcg/ml)

Max concentration: 400 mcg/ml

Diluent

D5, NS

Administration & Infusion rate

IV infusion

Initially administer 5 mcg/min, increase by 5 mcg/min every 3 – 5 min to 20 mcg/min [1,2,3]

If no response, increase by 10 mcg/min every 3 – 5 min to 20 mcg/min [1,2,3]

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

40 hr 7 days

After dilution

40 hr 7 days

Remarks

Not to be used undiluted [1,2,3]

Invert the glass parenteral bottle several times following admixture to assure uniform dilution

Dilution and storage of GTN for

IV infusion

should be done only in glass parenteral solution bottles