TOCILIZUMAB

Brand Name & Strength

Actemra® 80 mg/4 ml & 400 mg/20 ml

Reconstitution

Not required

Further Dilution

IV infusion

≥ 30 kg: Dilute to 100 ml with diluent < 30 kg: Dilute to 50 ml with diluent The volume of NS solution removed is equal to the volume of Tocilizumab solution required for the patients’ dose

Diluent

NS

Administration & Infusion rate

IV infusion

Administer over 1 hr

Storage & Stability

RT

(<30 oC)

Fridge

(2 – 8 oC)

After Reconstitution

- -

After dilution

24 hr 24 hr

Remarks

Do not administer IV push or

IV bolus

Allow diluted solution for infusion to reach room temperature prior to administration Gently invert to mix (avoid foaming) Diluted solution should be protected from light