ursodeoxycholic acid

Dissolution of gallstones Primary biliary cirrhosis

Dissolution of gallstones: 8–12 mg/kg/day in 1–2 divided doses Primary biliary cirrhosis: 10–15 mg/kg/day in 2–4 divided doses

Molecular weight : 392.6

%Protein binding : 96–98

%Excreted unchanged in urine : 0

Volume of distribution (L/kg) : No data

half-life – normal/ESRD (hrs) : No data

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD : Unknown dialysability. Dose as in normal renal function

HD : Unknown dialysability. Dose as in normal renal function

HDF/high flux : Unknown dialysability. Dose as in normal renal function

CAV/VVHD : Unknown dialysability. Dose as in normal renal function

Potentially hazardous interactions with other drugs

Ciclosporin: unpredictably increases the absorption of ciclosporin in some patients

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Oral

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Completely metabolised in the liver and excreted via the faecal route