sibutramine hydrochloride
sibutramine hydrochloride.JPG

CLINICAL USE

Treatment of obesity for patients who have not responded to appropriate weight reducing methods

DOSE IN NORMAL RENAL FUNCTION

10–15 mg daily

PHARMACOKINETICS

  • Molecular weight                           :334.3
  • %Protein binding                           :97
  • %Excreted unchanged in urine     : Only inactive metabolites
  • Volume of distribution (L/kg)       :No data
  • half-life – normal/ESRD (hrs)      :14–16

    DOSE IN RENAL IMPAIRMENT

    GFR (mL/MIN)

  • 20 to 50     : Dose as in normal renal function. Use with caution
  • 10 to 20     : Dose as in normal renal function. Use with caution
  • <10           : Dose as in normal renal function. Use with caution

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES

  • CAPD                :Unlikely to be dialysed. Dose as in GFR <10 mL/min
  • HD                     :Unlikely to be dialysed. Dose as in GFR <10 mL/min
  • HDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/min
  • CAV/VVHD      :Unknown dialysability. Dose as in GFR 10 to 20 mL/min

    IMPORTANT DRUG INTERACTIONS

    Potentially hazardous interactions with other drugs
  • Antidepressants: increased risk of CNS toxicity; avoid concomitant administration with MAOIs and moclobemide – avoid for at least 2 weeks after stopping sibutramine; increased CNS toxicity with noradrenaline re-uptake inhibitors, tricyclics, SSRIs, mirtazapine and tryptophan – avoid concomitant use with tryptophan
  • Antipsychotics: increased risk of CNS toxicity – avoid concomitant useAvoid use with drugs which increase heart rate or blood pressure

    ADMINISTRATION

    Reconstition

    Route

    Oral

    Rate of Administration

    Comments

    OTHER INFORMATION

    Do not use in patients with uncontrolled hypertension, i.e. BP >145/90 mmHgInitiation of therapy is associated with a mean increase in resting systolic and diastolic BP of 2–3 mmHg



    See how to identify renal failure stages according to GFR calculation

    See how to diagnose irreversible renal disease

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