rimonabant
CLINICAL USE
Treatment for obesity in conjunction with diet and exercise
DOSE IN NORMAL RENAL FUNCTION
20 mg daily before breakfast
PHARMACOKINETICS
Molecular weight                           :463.8 %Protein binding                           :>99.9 %Excreted unchanged in urine     : 3 Volume of distribution (L/kg)       :Depends on body weight (higher in obese patients)half-life – normal/ESRD (hrs)      :9 days (16 days in obese patients) DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50     : Dose as in normal renal function 10 to 20     : Dose as in normal renal function <10           : Dose as in normal renal function. Use with caution DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD                :Unlikely to be dialysed. Dose as in GFR <10 mL/min HD                     :Unlikely to be dialysed. Dose as in GFR <10 mL/minHDF/high flux   :Unknown dialysability. Dose as in GFR <10 mL/minCAV/VVHD      :Unknown dialysability. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsKetoconazole: concentration of rimonabant increased ADMINISTRATION
Reconstition
– Route
Oral Rate of Administration
–Comments
– OTHER INFORMATION
Manufacturer states use contraindicated in CKD 5 due to lack of dataDo not use in patients with major depression or who are on an antidepressant as there is a high risk of depression reported with rimonabant.
See how to identify renal failure stages according to GFR calculation
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