rabeprazole sodium

Gastric acid suppression

10–120 mg daily, doses >100 mg in 2 divided doses

Molecular weight :381.4

%Protein binding :97

%Excreted unchanged in urine : 0 (90 as metabolites)

Volume of distribution (L/kg) :0.34

half-life – normal/ESRD (hrs) :0.7–1.5/Unchanged

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : Dose as in normal renal function

CAPD :Unlikely to be dialysed. Dose as in normal renal function

HD :Not dialysed. Dose as in normal renal function

HDF/high flux :Unlikely to be dialysed. Dose as in normal renal function

CAV/VVHD :Unlikely to be dialysed. Dose as in normal renal function

Potentially hazardous interactions with other drugs

Antifungals: absorption of itraconazole and ketoconazole reduced

–

Oral

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Interstitial nephritis has been reported with rabeprazole sodium.